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2 edition of synthesis of enominone derivatives of norpethidine found in the catalog.

synthesis of enominone derivatives of norpethidine

Mohammad Ashraf Moten

synthesis of enominone derivatives of norpethidine

the preparation of a series of nor-pethidine enaminones for pharmacological evaluation, with particular reference to the tetronic and homotetronic acid derivatives.

by Mohammad Ashraf Moten

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Published by The author in Bradford .
Written in English


Edition Notes

M.Sc. thesis.

SeriesTheses
The Physical Object
Pagination123p.
Number of Pages123
ID Numbers
Open LibraryOL21483852M

  Synthesis of Fluorine‐Containing Heterocycles from α,α‐Dihydropolyfluoroalkylsulfides and Fluorinated Thiocarboxylic Acids Derivatives. Vadim M. Timoshemko. Institute of Organic Chemistry, NAS of Ukraine, Murmanskaya str.5, , Kiev, Ukraine Preparation of Enaminone [9] Preparation of Alkanoyl Vinylic Ether [10] Preparation of Author: Vadim M. Timoshemko, Yuriy G. Shermolovich.   The diazonium salts 11a or 11b coupled with compound 2 to yield the pyrazolo[5,1‐c]‐1,2,4‐triazine and 1,2,4‐triazolo[5,1‐c]‐1,2,4‐triazine derivatives 13a and 13b. Some of the newly synthesized compounds exhibited a moderate effect against some bacterial and fungal by:

A straightforward strategy for synthesis of highly functionalized trifluoromethyl 2H-furans is copper catalyzed method relies on a cascade cyclic reaction between enaminones and method allows the synthesis of 2-aminotrifluoromethyl-substituted 2H-furan derivatives carrying a quaternary stereogenic center as single : Xiaoyu Liang, Pan Guo, Wenjie Yang, Meng Li, Chengzhou Jiang, Wangbin Sun, Teck-Peng Loh, Yaojia Jia. Synthesis of Fluorine‐Containing Heterocycles from α,α‐Dihydropolyfluoroalkylsulfides and Fluorinated Thiocarboxylic Acids Derivatives Vadim M. Timoshemko Institute of Organic Chemistry, NAS of Ukraine, Murmanskaya str.5, , Kiev, UkraineAuthor: Vadim M. Timoshemko, Yuriy G. Shermolovich.

A visible-light induced photocatalytic aerobic oxidative dehydrogenative coupling/aromatization tandem reaction of glycine esters with unactivated alkenes has been accomplished. This visible light-driven protocol has been successfully applied to a broad scope of glycine esters and simple alkenes, giving rise to diverse substituted quinoline derivatives in 18–84% yield under mild (at room Cited by: Finally, the dihydropyrimidinone derivatives (1–20) were obtained by reacting enaminones (IIa–b) with urea and different substituted benzaldehydes in the presence of glacial acetic acid. Dihydropyrimidinone derivatives containing piperazine/morpholine moiety were synthesized in a good yield by means of simple and efficient by: 4.


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Synthesis of enominone derivatives of norpethidine by Mohammad Ashraf Moten Download PDF EPUB FB2

Synthesis of enaminones. Recent Literature. Simple and direct nucleophilic addition of secondary amines to 1,2,3-triazine under mild reaction conditions cleanly provides β-aminoenals in good yields. The reaction proceeds by amine nucleophilic addition to C4 of the 1,2,3-triazine, in situ loss of N 2, and subsequent imine hydrolysis.

The simple thiadiazole‐enaminone (6) was used as a synthetic precursor for the synthesis of a wide variety of new heterocyclic compounds, including the 5‐substituted‐1,3,4‐thiadiazole derivatives (7), (8), (16), (17) and (18), which were obtained via reactions of (6) with nitrogen by: 4.

Enaminones are synthesized by the rhodium(II)-catalyzed denitrogenative rearrangement reaction of 1-(N-sulfonyl-1,2,3-triazolyl)alkanols, which are readily prepared from propargylic alcohols and Enaminones are synthesized by the rhodium(II)-catalyzed denitrogenative rearrangement reaction of 1-(N-sulfonyl-1,2,3-triazolyl)alkanols, which are readily prepared from propargylic alcohols and Cited by: Enaminone 2 reacted with 3-amino-1H-1,2,4-triazole in acetic acid under reflux to afford [1,2,4]triazolo[4,3-a]pyrimidine derivatives (10) via the addition of the exoamino group of aminotriazole to α,β-unsaturated moiety in compound 2 followed by synthesis of enominone derivatives of norpethidine book of dimethylamine molecule to yield the corresponding acyclic non-isolable Cited by: 5.

A one-pot protocol for the synthesis of 2,3-diarylbenzo[b]furan derivatives through an N-heterocyclic carbene (NHC) catalyzed 1,6-conjugate addition of aromatic aldehydes to 2-hydroxyphenyl. Abstract. A regioselective synthesis of enamine and enaminone derivatives of fused cycloalkeno thieno[2,3-d]pyrimidin-4(3H)-ones is enamine versus enaminone product in the condensation reaction with N,N-dimethylformamide dimethylacetal (DMFDMA) was shown to depend on the conformation of the cycloalkeno ring fused to the pyrimidinone by: 3.

Thieme E-Books & E-Journals. Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FLUSA; Fax +1()3 92 91 99; E-mail: [email protected] by: A transition-metal-free synthesis of pyridine derivatives by 6-endo-dig cyclization of N-propargyl enamines was developed.

This method is environmentally friendly and is a high atom economy reaction that is easily accessed to provide pyridine derivatives in moderate to good yield by heating N -propargyl enamines in solvent without : Yuya Chikayuki, Takakane Miyashige, Shiori Yonekawa, Akiko Kirita, Natsuko Matsuo, Hiroyoshi Teramot.

Also, the reaction of 6a,b,d-f,h with glycine and hippuric acid in acetic anhydride afforded pyridazinone derivatives 17a-f. Synthesis of pyridazine carboxylic acid derivatives 22a,b from the. the α-carbon atom of the enaminone.

The new 2-substituted derivatives of 2,3-dihydrobenzimidazole are interesting both from synthetic point of view and as potential bioactive compounds. All the synthesized benzimidazole derivatives were assayed for antimicrobial activity using standardized tests (DM and DDM) against seven strains microorganisms.

Synthesis and antimicrobial evaluations of some novel To determine the in fl uence of the acyl component, we initially studied the reactions of two different N-acyliminium compounds 3 with. Summary This chapter contains sections titled: Introduction Synthesis of Pyrrole Natural Products Synthesis of Non‐pyrrole Natural Products from Pyrrole Derivatives Cited by: 7.

published patents for the synthesis of Brimonidine and its derivatives, Some of relevant patents are USUSUS, RUUSGB Process of synthesis of Brimonidine as given in US involves the use of benzene which is carcinogenic and hence prohibited by all health agencies Size: KB. Two variations of a parallel solution-phase synthesis of N-substituted dimethyl 4-oxo-1,4-dihydropyridine-3,5-dicarboxylates 4 and methyl 3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]pyridinecarboxylates 9 from dimethyl acetone-1,3-dicarboxylate (1) were developed.

The first synthetic method comprises preparation of the bis-enaminone reagents 2 and 8 and their cyclization with primary Cited by: 9. Novel series of thioureido-benzenesulfonamide derivatives bearing an enaminone linker either meta or para oriented and having terminal linear or substituted aromatic or heteroaromatic ring system 5–16a,b were designed and synthesized based on the general pharmacophoric features of Cited by: 3.

As a result, the novel one-pot synthesis of 2,3,4,5-tetrahydro-1H-1,5-benzodiazepinecarboxamide derivatives using an aromatic diamine, a linear or cyclic ketone, an isocyanide, and water in the presence of a catalytic amount of p-toluenesulfonic acid at.

The cationic N-heterocyclic carbene−gold(I) complex catalyzes the formation of tri- and tetrasubstituted pyrroles via the amino−Claisen rearrangement of N-propargyl β-enaminone derivatives and the cyclization of α-allenyl β-enaminone by: The greenest solvent, in terms of reducing waste, is no solvent.

Due to the toxic, flammable, and expensive nature of organic solvents, 1 special emphasis has been placed toward solvent-free reactions. Overall the advantages of solvent-free organic synthesis are shorter reaction times, cleaner reaction products, and environmentally more benign conditions compared with the classical reactions Cited by: Norpethidine (normeperidine, pethidine intermediate B) is a 4-phenylpiperidine derivative that is both a precursor to, and the toxic metabolite of, pethidine (meperidine).

It is scheduled by UN Single Convention on Narcotic is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of The annual manufacturing quota was 11 grams ( oz).ATC code: none. Enaminone. Enaminones are compounds containing the system N–C=C–C=O. They are mono enamines of 1, 3-diketones (vinylogous amides) or enamines of 3-keto esters (vinylogous urethanes).

From: Advances in Heterocyclic Chemistry, Download as PDF. Enamination of acetoacetamides with Boc-monoprotected ethylenediamine provides β-enamino amides, which can be acylated at the α-carbon with excellent selectivity. These C-acylated derivatives undergo domino fragmentation in acidic media to give the corresponding β-keto amides accompanied by 2-methyl-4,5-dihydro-1H-imidazole.Results.

Synthesis of (2E,2′E)-1,1′-(3,4-diphenylthieno [2,3-b] thiophene-2,5-diyl) bis (3-(dimethylamino) propenone) 5 was reported. The structure of compound 5 was deduced by spectroscopic techniques.

The compound was crystallizes in the monoclinic system with space group P-1 with cell coordinates a= (8) Å, b= (8) Å, c= (11) Å, α= (2) °, β= (2 Cited by: A novel chiral pyrazole derivative was developed by our research program as a potent PDE4 inhibitor for the treatment of anti-inflammatory diseases, such as asthma and chronic obstructive pulmonary disease.

The asymmetric synthesis of the inhibitors carrying the pyrazole moiety, including nitrogen directly bCited by: